Title | Cerebral palsy and growth failure at 6 to 7 years. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Vohr BR, Stephens BE, McDonald SA, Ehrenkranz RA, Laptook AR, Pappas A, Hintz SR, Shankaran S, Higgins RD, Das A |
Corporate Authors | Extended Hypothermia Follow-up Subcommittee of the NICHD Neonatal Research Network |
Journal | Pediatrics |
Volume | 132 |
Issue | 4 |
Pagination | e905-14 |
Date Published | 2013 Oct |
ISSN | 1098-4275 |
Keywords | Cerebral Palsy, Child, Cohort Studies, Failure to Thrive, Female, Follow-Up Studies, Humans, Hypoxia-Ischemia, Brain, Infant, Longitudinal Studies, Male, Prospective Studies |
Abstract | OBJECTIVE: To evaluate the association between severity of cerebral palsy (CP) and growth to 6 to 7 years of age among children with moderate to severe (Mod/Sev) hypoxic ischemic encephalopathy (HIE). It was hypothesized that children with Mod/Sev CP would have poorer growth, lower cognitive scores, and increased rehospitalization rates compared with children with no CP (No CP). METHODS: Among 115 of 122 surviving children followed in the hypothermia trial for neonatal HIE, growth parameters and neurodevelopmental status at 18 to 22 months and 6 to 7 years were available. Group comparisons (Mod/Sev CP and No CP) with unadjusted and adjusted analyses for growth <10th percentile and z scores by using Fisher's exact tests and regression modeling were conducted. RESULTS: Children with Mod/Sev CP had high rates of slow growth and cognitive and motor impairment and rehospitalizations at 18 to 22 months and 6 to 7 years. At 6 to 7 years of age, children with Mod/Sev CP had increased rates of growth parameters <10th percentile compared with those with No CP (weight, 57% vs 3%; height, 70% vs 2%; and head circumference, 82% vs 13%; P < .0001). Increasing severity of slow growth was associated with increasing age (P < .04 for weight, P < .001 for length, and P < .0001 for head circumference). Gastrostomy feeds were associated with better growth. CONCLUSIONS: Term children with HIE who develop Mod/Sev CP have high and increasing rates of growth <10th percentile by 6 to 7 years of age. These findings support the need for close medical and nutrition management of children with HIE who develop CP. |
DOI | 10.1542/peds.2012-3915 |
Alternate Journal | Pediatrics |
PubMed ID | 24019415 |
PubMed Central ID | PMC3784290 |
Grant List | U10 HD027856 / HD / NICHD NIH HHS / United States U10 HD021373 / HD / NICHD NIH HHS / United States UL1 RR024139 / RR / NCRR NIH HHS / United States U10 HD021385 / HD / NICHD NIH HHS / United States U10 HD021364 / HD / NICHD NIH HHS / United States U10 HD027880 / HD / NICHD NIH HHS / United States U10 HD040521 / HD / NICHD NIH HHS / United States M01 RR008084 / RR / NCRR NIH HHS / United States U10 HD27904 / HD / NICHD NIH HHS / United States U10 HD040461 / HD / NICHD NIH HHS / United States M01 RR016587 / RR / NCRR NIH HHS / United States U10 HD040689 / HD / NICHD NIH HHS / United States U10 HD040492 / HD / NICHD NIH HHS / United States U10 HD027853 / HD / NICHD NIH HHS / United States U10 HD027904 / HD / NICHD NIH HHS / United States U10 HD021397 / HD / NICHD NIH HHS / United States UL1 TR000439 / TR / NCATS NIH HHS / United States U10 HD027871 / HD / NICHD NIH HHS / United States U10 HD027851 / HD / NICHD NIH HHS / United States M01 RR80 / RR / NCRR NIH HHS / United States U10HD21364 / HD / NICHD NIH HHS / United States U10 HD034216 / HD / NICHD NIH HHS / United States U10 HD036790 / HD / NICHD NIH HHS / United States |