|Title||Change in neonatal resuscitation guidelines and trends in incidence of meconium aspiration syndrome in California.|
|Publication Type||Journal Article|
|Year of Publication||2020|
|Authors||Kalra VK, Lee HC, Sie L, Ratnasiri AW, Underwood MA, Lakshminrusimha S|
|Date Published||2020 01|
|Keywords||Administration, Inhalation, California, Extracorporeal Membrane Oxygenation, Humans, Incidence, Infant, Newborn, Infant, Newborn, Diseases, Intensive Care Units, Neonatal, Intubation, Intratracheal, Meconium Aspiration Syndrome, Nitric Oxide, Practice Guidelines as Topic, Respiration, Artificial, Resuscitation|
OBJECTIVE: To describe trends in the incidence and severity of meconium aspiration syndrome (MAS) around the release of revised Neonatal Resuscitation Program (NRP) guidelines in 2016.
STUDY DESIGN: The California Perinatal Quality Care Collaborative database was queried for years 2013-2017 to describe the incidence and outcomes of infants with MAS. Results were analyzed based on both individual years and pre- vs. post-guideline epochs (2013-15 vs. 2017).
RESULT: Incidence of MAS decreased significantly from 2013-15 to 2017 (1.02 to 0.78/1000 births, p < 0.001). Among infants with MAS, delivery room intubations decreased from 2013-15 to 2017 (44.3 vs. 35.1%; p = 0.005), but similar proportion of infants required invasive respiratory support (80.1 vs. 80.8%), inhaled nitric oxide (28.8 vs. 28.4%) or extracorporeal membrane oxygenation (0.81 vs. 0.35%).
CONCLUSION: While the study design precludes confirmation of implementation of the recent NRP recommendation, there was no increase in the incidence or severity of MAS following its release.
|Alternate Journal||J Perinatol|
|Grant List||HD 072929 / / Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) / International|