|Title||Combined elevated midpregnancy tumor necrosis factor alpha and hyperlipidemia in pregnancies resulting in early preterm birth.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Jelliffe-Pawlowski LL, Ryckman KK, Bedell B, O'Brodovich HM, Gould JB, Lyell DJ, Borowski KS, Shaw GM, Murray JC, Stevenson DK|
|Journal||Am J Obstet Gynecol|
|Date Published||2014 Aug|
|Keywords||Adolescent, Adult, Body Mass Index, California, Case-Control Studies, Female, Humans, Hyperlipidemias, Infant, Newborn, Iowa, Lipids, Pregnancy, Pregnancy Complications, Pregnancy Trimester, Second, Premature Birth, Tumor Necrosis Factor-alpha, Young Adult|
OBJECTIVE: The objective of the study was to determine whether pregnancies resulting in early preterm birth (PTB) (<30 weeks) were more likely than term pregnancies to have elevated midtrimester serum tumor necrosis factor alpha (TNF-α) levels combined with lipid patterns suggestive of hyperlipidemia.
STUDY DESIGN: In 2 nested case-control samples drawn from California and Iowa cohorts, we examined the frequency of elevated midpregnancy serum TNF-α levels (in the fourth quartile [4Q]) and lipid patterns suggestive of hyperlipidemia (eg, total cholesterol, low-density-lipoproteins, or triglycerides in the 4Q, high-density lipoproteins in the first quartile) (considered independently and by co-occurrence) in pregnancies resulting in early PTB compared with those resulting in term birth (n = 108 in California and n = 734 in Iowa). Odds ratios (ORs) and 95% confidence intervals (CIs) estimated in logistic regression models were used for comparisons.
RESULTS: Early preterm pregnancies were 2-4 times more likely than term pregnancies to have a TNF-α level in the 4Q co-occurring with indicators of hyperlipidemia (37.5% vs 13.9% in the California sample (adjusted OR, 4.0; 95% CI, 1.1-16.3) and 26.3% vs 14.9% in the Iowa sample (adjusted OR, 2.7; 95% CI, 1.1-6.3). No differences between early preterm and term pregnancies were observed when TNF-α or target lipid abnormalities occurred in isolation. Observed differences were not explicable to any maternal or infant characteristics.
CONCLUSION: Pregnancies resulting in early PTB were more likely than term pregnancies to have elevated midpregnancy TNF-α levels in combination with lipid patterns suggestive of hyperlipidemia.
|Alternate Journal||Am J Obstet Gynecol|
|PubMed Central ID||PMC4117727|
|Grant List||K12 HD000849 / HD / NICHD NIH HHS / United States |
R01 HD057192 / HD / NICHD NIH HHS / United States
R01 HD-52953 / HD / NICHD NIH HHS / United States
R01 HD-57192 / HD / NICHD NIH HHS / United States
R01 HD052953 / HD / NICHD NIH HHS / United States
RC2 HL101748 / HL / NHLBI NIH HHS / United States
SDR 10-180 / HX / HSRD VA / United States