| Title | Does active treatment in infants born at 22-23 weeks correlate with outcomes of more mature infants at the same hospital? An analysis of California NICU data, 2015-2019. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Bane S, Rysavy MA, Carmichael SL, Lu T, Bennett M, Lee HC |
| Journal | J Perinatol |
| Volume | 42 |
| Issue | 10 |
| Pagination | 1301-1305 |
| Date Published | 2022 Oct |
| ISSN | 1476-5543 |
| Keywords | Epinephrine, Female, Gestational Age, Hospitals, Humans, Infant, Infant Mortality, Infant, Newborn, Intensive Care Units, Neonatal, Intubation, Intratracheal, Pregnancy |
| Abstract | OBJECTIVE: To investigate whether hospital rates of active treatment for infants born at 22-23 weeks is associated with survival of infants born at 24-27 weeks. STUDY DESIGN: We included all liveborn infants 22-27 weeks of gestation delivered at California Perinatal Quality Care Collaborative hospitals from 2015 to 2019. We assessed (1) the correlation of active treatment (e.g., endotracheal intubation, epinephrine) in 22-23 week infants and survival until discharge for 24-27 week infants and (2) the association of active treatment with survival using multilevel models. RESULT: The 22-23 week active treatment rate was associated with infant outcomes at 22-23 weeks but not 24-27 weeks. A 10% increase in active treatment did not relate to 24-25 week (adjusted OR: 1.00 [95% CI: 0.95-1.05]), or 26-27 week survival (aOR: 1.02 [0.95-1.09]). CONCLUSION: The hospital rate of active treatment for infants born at 22-23 weeks was not associated with improved survival for 24-27 week infants. |
| DOI | 10.1038/s41372-022-01381-x |
| Alternate Journal | J Perinatol |
| PubMed ID | 35361887 |
| PubMed Central ID | PMC9522931 |
| Grant List | R01 HD098287 / HD / NICHD NIH HHS / United States |
