Title | A genome-wide association study identifies only two ancestry specific variants associated with spontaneous preterm birth. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Rappoport N, Toung J, Hadley D, Wong RJ, Fujioka K, Reuter J, Abbott CW, Oh S, Hu D, Eng C, Huntsman S, Bodian DL, Niederhuber JE, Hong X, Zhang G, Sikora-Wohfeld W, Gignoux CR, Wang H, Oehlert J, Jelliffe-Pawlowski LL, Gould JB, Darmstadt GL, Wang X, Bustamante CD, Snyder MP, Ziv E, Patsopoulos NA, Muglia LJ, Burchard E, Shaw GM, O'Brodovich HM, Stevenson DK, Butte AJ, Sirota M |
Journal | Sci Rep |
Volume | 8 |
Issue | 1 |
Pagination | 226 |
Date Published | 2018 01 09 |
ISSN | 2045-2322 |
Keywords | Adult, Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 8, Continental Population Groups, Female, Humans, Infant, Newborn, Male, Middle Aged, Polymorphism, Single Nucleotide, Premature Birth |
Abstract | Preterm birth (PTB), or the delivery prior to 37 weeks of gestation, is a significant cause of infant morbidity and mortality. Although twin studies estimate that maternal genetic contributions account for approximately 30% of the incidence of PTB, and other studies reported fetal gene polymorphism association, to date no consistent associations have been identified. In this study, we performed the largest reported genome-wide association study analysis on 1,349 cases of PTB and 12,595 ancestry-matched controls from the focusing on genomic fetal signals. We tested over 2 million single nucleotide polymorphisms (SNPs) for associations with PTB across five subpopulations: African (AFR), the Americas (AMR), European, South Asian, and East Asian. We identified only two intergenic loci associated with PTB at a genome-wide level of significance: rs17591250 (P = 4.55E-09) on chromosome 1 in the AFR population and rs1979081 (P = 3.72E-08) on chromosome 8 in the AMR group. We have queried several existing replication cohorts and found no support of these associations. We conclude that the fetal genetic contribution to PTB is unlikely due to single common genetic variant, but could be explained by interactions of multiple common variants, or of rare variants affected by environmental influences, all not detectable using a GWAS alone. |
DOI | 10.1038/s41598-017-18246-5 |
Alternate Journal | Sci Rep |
PubMed ID | 29317701 |
PubMed Central ID | PMC5760643 |
Grant List | K01 LM012381 / LM / NLM NIH HHS / United States P50 HG007735 / HG / NHGRI NIH HHS / United States T32 HG000044 / HG / NHGRI NIH HHS / United States |