| Title | Inhaled nitric oxide use in preterm infants in California neonatal intensive care units. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Handley SC, Steinhorn RH, Hopper AO, Govindaswami B, Bhatt DR, Van Meurs KP, Ariagno RL, Gould JB, Lee HC |
| Journal | J Perinatol |
| Volume | 36 |
| Issue | 8 |
| Pagination | 635-9 |
| Date Published | 2016 08 |
| ISSN | 1476-5543 |
| Keywords | Administration, Inhalation, Bronchodilator Agents, California, Female, Gestational Age, Humans, Infant, Extremely Premature, Infant, Newborn, Infant, Premature, Diseases, Intensive Care Units, Neonatal, Logistic Models, Male, Multivariate Analysis, Nitric Oxide, Retrospective Studies |
| Abstract | OBJECTIVE: To describe inhaled nitric oxide (iNO) exposure in preterm infants and variation in neonatal intensive care unit (NICU) use. STUDY DESIGN: This was a retrospective cohort study of infants, 22 to 33+6/7 weeks of gestational age (GA), during 2005 to 2013. Analyses were stratified by GA and included population characteristics, iNO use over time and hospital variation. RESULTS: Of the 65 824 infants, 1718 (2.61%) received iNO. Infants, 22 to 24+6/7 weeks of GA, had the highest incidence of iNO exposure (6.54%). Community NICUs (n=77, median hospital use rate 0.7%) used less iNO than regional NICUs (n=23, median hospital use rate 5.8%). In 22 to 24+6/7 weeks of GA infants, the median rate in regional centers was 10.6% (hospital interquartile range 3.8% to 22.6%). CONCLUSION: iNO exposure varied with GA and hospital level, with the most use in extremely premature infants and regional centers. Variation reflects a lack of consensus regarding the appropriate use of iNO for preterm infants. |
| DOI | 10.1038/jp.2016.49 |
| Alternate Journal | J Perinatol |
| PubMed ID | 27031320 |
| PubMed Central ID | PMC4963282 |
| Grant List | K23 HD068400 / HD / NICHD NIH HHS / United States |
