|Title||Inhaled nitric oxide use in preterm infants in California neonatal intensive care units.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Handley SC, Steinhorn RH, Hopper AO, Govindaswami B, Bhatt DR, Van Meurs KP, Ariagno RL, Gould JB, Lee HC|
|Date Published||2016 08|
|Keywords||Administration, Inhalation, Bronchodilator Agents, California, Female, Gestational Age, Humans, Infant, Extremely Premature, Infant, Newborn, Infant, Premature, Diseases, Intensive Care Units, Neonatal, Logistic Models, Male, Multivariate Analysis, Nitric Oxide, Retrospective Studies|
OBJECTIVE: To describe inhaled nitric oxide (iNO) exposure in preterm infants and variation in neonatal intensive care unit (NICU) use.
STUDY DESIGN: This was a retrospective cohort study of infants, 22 to 33+6/7 weeks of gestational age (GA), during 2005 to 2013. Analyses were stratified by GA and included population characteristics, iNO use over time and hospital variation.
RESULTS: Of the 65 824 infants, 1718 (2.61%) received iNO. Infants, 22 to 24+6/7 weeks of GA, had the highest incidence of iNO exposure (6.54%). Community NICUs (n=77, median hospital use rate 0.7%) used less iNO than regional NICUs (n=23, median hospital use rate 5.8%). In 22 to 24+6/7 weeks of GA infants, the median rate in regional centers was 10.6% (hospital interquartile range 3.8% to 22.6%).
CONCLUSION: iNO exposure varied with GA and hospital level, with the most use in extremely premature infants and regional centers. Variation reflects a lack of consensus regarding the appropriate use of iNO for preterm infants.
|Alternate Journal||J Perinatol|
|PubMed Central ID||PMC4963282|
|Grant List||K23 HD068400 / HD / NICHD NIH HHS / United States|