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Investigation of maternal environmental exposures in association with self-reported preterm birth.

CPQCC Publication
TitleInvestigation of maternal environmental exposures in association with self-reported preterm birth.
Publication TypeJournal Article
Year of Publication2014
AuthorsPatel CJ, Yang T, Hu Z, Wen Q, Sung J, El-Sayed YY, Cohen H, Gould J, Stevenson DK, Shaw GM, Ling XBruce, Butte AJ
Corporate AuthorsMarch of Dimes Prematurity Research Center at Stanford University School of Medicine
JournalReprod Toxicol
Date Published2014 Jun
KeywordsAdult, Benzhydryl Compounds, Environmental Monitoring, Environmental Pollutants, Estrogens, Non-Steroidal, Female, Humans, Maternal Exposure, Nutrition Surveys, Phenols, Pregnancy, Premature Birth, Young Adult

Identification of maternal environmental factors influencing preterm birth risks is important to understand the reasons for the increase in prematurity since 1990. Here, we utilized a health survey, the US National Health and Nutrition Examination Survey (NHANES) to search for personal environmental factors associated with preterm birth. 201 urine and blood markers of environmental factors, such as allergens, pollutants, and nutrients were assayed in mothers (range of N: 49-724) who answered questions about any children born preterm (delivery <37 weeks). We screened each of the 201 factors for association with any child born preterm adjusting by age, race/ethnicity, education, and household income. We attempted to verify the top finding, urinary bisphenol A, in an independent study of pregnant women attending Lucile Packard Children's Hospital. We conclude that the association between maternal urinary levels of bisphenol A and preterm birth should be evaluated in a larger epidemiological investigation.

Alternate JournalReprod Toxicol
PubMed ID24373932
PubMed Central IDPMC4316205
Grant ListT32 HL007034 / HL / NHLBI NIH HHS / United States