Title | Neonatal oxygen saturations and blood pressure at school-age in children born extremely preterm: a cohort study. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Oren MS, Ianus V, Vohr BR, Hintz SR, Do BT, Das A, Shankaran S, Higgins RD, Watterberg KL |
Corporate Authors | Eunice Kennedy Shrive National Institute of Child Health and Human Development Neonatal Research Network |
Journal | J Perinatol |
Volume | 40 |
Issue | 6 |
Pagination | 902-908 |
Date Published | 2020 06 |
ISSN | 1476-5543 |
Abstract | OBJECTIVE: To explore the relationship between neonatal oxygen saturation and BP at age 6-7 years in a cohort of infants born extremely preterm. STUDY DESIGN: Infants <28 weeks gestation were assigned to a higher or lower oxygen saturation target. Oximeter data were monitored throughout the neonatal period. A subset of survivors was seen at age 6. BP was measured and compared by group assignment, achieved saturations, and time spent in hypoxemia (saturations <80%). RESULTS: There was no difference in systolic or diastolic BP between assigned groups. Median achieved weekly oxygen saturation was not associated with BP. Longer duration of hypoxemia during the first week of age was associated with higher systolic BP. CONCLUSIONS: Neither target nor actual median oxygen saturations in this study was associated with BP at school age. Increased duration of hypoxemia in the first postnatal week was associated with higher systolic BP at 6-7 years of age. |
DOI | 10.1038/s41372-020-0619-z |
Alternate Journal | J Perinatol |
PubMed ID | 32111975 |
PubMed Central ID | PMC7260090 |
Grant List | R01 HL117764 / HL / NHLBI NIH HHS / United States U10 HD053124 / HD / NICHD NIH HHS / United States U10 HD053119 / HD / NICHD NIH HHS / United States U10 HD021364 / HD / NICHD NIH HHS / United States M01 RR000039 / RR / NCRR NIH HHS / United States UL1 TR000442 / TR / NCATS NIH HHS / United States M01 RR000030 / RR / NCRR NIH HHS / United States M01 RR000633 / RR / NCRR NIH HHS / United States U01 HL112748 / HL / NHLBI NIH HHS / United States UL1 RR025744 / RR / NCRR NIH HHS / United States M01 RR000997 / RR / NCRR NIH HHS / United States M01 RR000064 / RR / NCRR NIH HHS / United States UL1 RR025008 / RR / NCRR NIH HHS / United States U24 HD095254 / HD / NICHD NIH HHS / United States U10 HD053089 / HD / NICHD NIH HHS / United States U10 HD027856 / HD / NICHD NIH HHS / United States U10 HD021373 / HD / NICHD NIH HHS / United States UG1 HD53089 / / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) / International U10 HD021385 / HD / NICHD NIH HHS / United States UG1 HD21385 / / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) / International U10 HD027880 / HD / NICHD NIH HHS / United States UG1 HD027853 / HD / NICHD NIH HHS / United States U10 HD053109 / HD / NICHD NIH HHS / United States UL1 TR001449 / TR / NCATS NIH HHS / United States UG1 HD053089 / HD / NICHD NIH HHS / United States U10 HD040461 / HD / NICHD NIH HHS / United States M01 RR000750 / RR / NCRR NIH HHS / United States M01 RR000059 / RR / NCRR NIH HHS / United States U10 DA24117 / / U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) / International U10 HD040689 / HD / NICHD NIH HHS / United States U10 HD040492 / HD / NICHD NIH HHS / United States M01 RR000054 / RR / NCRR NIH HHS / United States U10 HD027904 / HD / NICHD NIH HHS / United States U10 HD027851 / HD / NICHD NIH HHS / United States M01 RR000032 / RR / NCRR NIH HHS / United States M01 RR000070 / RR / NCRR NIH HHS / United States M01 RR000080 / RR / NCRR NIH HHS / United States U10 HD034216 / HD / NICHD NIH HHS / United States U10 HD036790 / HD / NICHD NIH HHS / United States |