|Title||Neurodevelopmental outcome of extremely low birth weight infants with Candida infection.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Adams-Chapman I, Bann CM, Das A, Goldberg RN, Stoll BJ, Walsh MC, Sánchez PJ, Higgins RD, Shankaran S, Watterberg KL, Duara S, Miller NA, Heyne RJ, Peralta-Carcelen M, Goldstein RF, Steichen JJ, Bauer CR, Hintz SR, Evans PW, Acarregui MJ, Myers GJ, Vohr BR, Wilson-Costello DE, Pappas A, Vaucher YE, Ehrenkranz RA, McGowan EC, Dillard RG, Fuller J, Benjamin DK|
|Corporate Authors||Eunice Kennedy Shriver National Institutes of Child Health and Human Development Neonatal Research Network|
|Date Published||2013 Oct|
|Keywords||Candida, Candidiasis, Databases, Factual, Developmental Disabilities, Female, Humans, Infant, Infant, Extremely Low Birth Weight, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Male, Meningitis, Fungal, Prospective Studies, Risk Factors, Sepsis|
OBJECTIVE: Candida remains an important cause of late-onset infection in preterm infants. Mortality and neurodevelopmental outcome of extremely low birth weight (ELBW) infants enrolled in the Candida study were evaluated based on infection status.
STUDY DESIGN: ELBW infants born at Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NRN) centers between March 2004 and July 2007 who were screened for suspected sepsis were eligible for inclusion in the Candida study. Primary outcome data for neurodevelopmental impairment (NDI) or death were available for 1317 of the 1515 infants (87%) enrolled in the Candida study. The Bayley Scales of Infant Development-II or -III was administered at 18 months' adjusted age. A secondary comparison was performed with 864 infants enrolled in the NRN Generic Database during the same cohort who were never screened for sepsis and therefore not eligible for the Candida study.
RESULTS: Among ELBW infants enrolled in the Candida study, 31% with Candida and 31% with late-onset non-Candida sepsis had NDI at 18 months. Infants with Candida sepsis and/or meningitis had an increased risk of death and were more likely to have the composite outcome of death and/or NDI compared with uninfected infants in adjusted analysis. Compared with infants in the NRN registry never screened for sepsis, overall risk for death were similar but those with Candida infection were more likely to have NDI (OR 1.83, 95% CI 1.01-3.33, P = .047).
CONCLUSIONS: In this cohort of ELBW infants, those with infection and/or meningitis were at increased risk for death and/or NDI. This risk was highest among those with Candida sepsis and/or meningitis.
|Alternate Journal||J Pediatr|
|PubMed Central ID||PMC3786056|
|Grant List||U10 HD021364 / HD / NICHD NIH HHS / United States |
UL1 TR001449 / TR / NCATS NIH HHS / United States
K23 HD044799 / HD / NICHD NIH HHS / United States
U10 HD040461 / HD / NICHD NIH HHS / United States
U10 HD27856 / HD / NICHD NIH HHS / United States
UL1 TR000439 / TR / NCATS NIH HHS / United States
M01 RR750 / RR / NCRR NIH HHS / United States
UG1 HD027851 / HD / NICHD NIH HHS / United States
U10 HD027856 / HD / NICHD NIH HHS / United States
U10 HD021373 / HD / NICHD NIH HHS / United States
UL1 TR000041 / TR / NCATS NIH HHS / United States
U10 HD027851 / HD / NICHD NIH HHS / United States