|Title||Neuroimaging and Bayley-III correlates of early hand function in extremely preterm children.|
|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Duncan AF, Bann CM, Dempsey AG, Adams-Chapman I, Heyne R, Hintz SR|
|Corporate Authors||Eunice Kennedy Shriver National Institute of Child Health and Development Neonatal Research Network|
|Date Published||2019 03|
|Keywords||Brain, Cohort Studies, Developmental Disabilities, Echoencephalography, Female, Hand, Humans, Infant, Infant, Extremely Premature, Linear Models, Magnetic Resonance Imaging, Male, Neuropsychological Tests|
OBJECTIVE(S): Investigate associations between 18 and 22-month corrected age hand function, adverse findings on serial cranial ultrasound (CUS) and near-term brain MRI (ntMRI), and Bayley-III scores in extremely preterm (EPT) toddlers.
STUDY DESIGN: Cohort analysis of Neonatal Research Network SUPPORT NEURO data. Associations between brain abnormalities, hand function, and Bayley-III scores were examined using chi-square and generalized linear mixed effect model analyses.
RESULTS: A total of 433 children were included. Sixteen percent had hand function deficits; these were associated with late CUS (p < 0.001) abnormalities, white matter abnormality (WMA) on ntMRI (p < 0.001), and Bayley-III scores. Six percent had CP. Fourteen percent of children without and 50% of those with CP had hand function abnormalities.
CONCLUSIONS: Late CUS findings and severity of WMA were significantly associated with hand function deficits. Hand function deficits were nearly three times more common than CP and may be a useful marker of early brain insult and predictor of preterm birth effects on development.
|Alternate Journal||J Perinatol|
|PubMed Central ID||PMC7092795|
|Grant List||U10 HD021373 / HD / NICHD NIH HHS / United States |
UG1 HD087226 / HD / NICHD NIH HHS / United States