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Neuroimaging and Bayley-III correlates of early hand function in extremely preterm children.

CPQCC Publication
TitleNeuroimaging and Bayley-III correlates of early hand function in extremely preterm children.
Publication TypeJournal Article
Year of Publication2019
AuthorsDuncan AF, Bann CM, Dempsey AG, Adams-Chapman I, Heyne R, Hintz SR
Corporate AuthorsEunice Kennedy Shriver National Institute of Child Health and Development Neonatal Research Network
JournalJ Perinatol
Date Published2019 03
KeywordsBrain, Cohort Studies, Developmental Disabilities, Echoencephalography, Female, Hand, Humans, Infant, Infant, Extremely Premature, Linear Models, Magnetic Resonance Imaging, Male, Neuropsychological Tests

OBJECTIVE(S): Investigate associations between 18 and 22-month corrected age hand function, adverse findings on serial cranial ultrasound (CUS) and near-term brain MRI (ntMRI), and Bayley-III scores in extremely preterm (EPT) toddlers.

STUDY DESIGN: Cohort analysis of Neonatal Research Network SUPPORT NEURO data. Associations between brain abnormalities, hand function, and Bayley-III scores were examined using chi-square and generalized linear mixed effect model analyses.

RESULTS: A total of 433 children were included. Sixteen percent had hand function deficits; these were associated with late CUS (p < 0.001) abnormalities, white matter abnormality (WMA) on ntMRI (p < 0.001), and Bayley-III scores. Six percent had CP. Fourteen percent of children without and 50% of those with CP had hand function abnormalities.

CONCLUSIONS: Late CUS findings and severity of WMA were significantly associated with hand function deficits. Hand function deficits were nearly three times more common than CP and may be a useful marker of early brain insult and predictor of preterm birth effects on development.

Alternate JournalJ Perinatol
PubMed ID30692613
PubMed Central IDPMC7092795
Grant ListU10 HD021373 / HD / NICHD NIH HHS / United States
UG1 HD087226 / HD / NICHD NIH HHS / United States