| Title | Outcomes of extremely preterm infants after delivery room cardiopulmonary resuscitation in a population-based cohort. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Handley SC, Sun Y, Wyckoff MH, Lee HC |
| Journal | J Perinatol |
| Volume | 35 |
| Issue | 5 |
| Pagination | 379-83 |
| Date Published | 2015 May |
| ISSN | 1476-5543 |
| Keywords | California, Cardiopulmonary Resuscitation, Cohort Studies, Delivery Rooms, Epinephrine, Female, Gestational Age, Heart Massage, Humans, Infant, Extremely Low Birth Weight, Infant, Extremely Premature, Infant, Newborn, Male, Multivariate Analysis, Odds Ratio, Regression Analysis, Treatment Outcome |
| Abstract | OBJECTIVE: To describe the relationship of delivery room cardiopulmonary resuscitation (DR-CPR) to short-term outcomes of extremely preterm infants. STUDY DESIGN: This was a cohort study of 22 to 27+6/7 weeks gestational age (GA) infants during 2005 to 2011. DR-CPR was defined as chest compressions and/or epinephrine administration. Multivariable logistic regression was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) associated with DR-CPR; analysis was stratified by GA. RESULT: Of the 13 758 infants, 856 (6.2%) received DR-CPR. Infants 22 to 23+6/7 weeks receiving DR-CPR had similar outcomes to non-recipients. Infants 24 to 25+6/7 weeks receiving DR-CPR had more severe intraventricular hemorrhage (OR 1.36, 95% CI 1.07, 1.72). Infants 26 to 27+6/7 weeks receiving DR-CPR were more likely to die (OR 1.81, 95% CI 1.30, 2.51) and have intraventricular hemorrhage (OR 2.10, 95% CI 1.56, 2.82). Adjusted hospital DR-CPR rates varied widely (median 5.7%). CONCLUSION: Premature infants receiving DR-CPR had worse outcomes. Mortality and morbidity varied by GA. |
| DOI | 10.1038/jp.2014.222 |
| Alternate Journal | J Perinatol |
| PubMed ID | 25521563 |
| PubMed Central ID | PMC4414658 |
| Grant List | K23 HD068400 / HD / NICHD NIH HHS / United States K23HD068400 / HD / NICHD NIH HHS / United States |
