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Prenatal and postnatal inflammation-related risk factors for retinopathy of prematurity.

CPQCC Publication
TitlePrenatal and postnatal inflammation-related risk factors for retinopathy of prematurity.
Publication TypeJournal Article
Year of Publication2019
AuthorsGoldstein GP, Leonard SA, Kan P, Koo EB, Lee HC, Carmichael SL
JournalJ Perinatol
Date Published2019 07
KeywordsBronchopulmonary Dysplasia, Cerebral Intraventricular Hemorrhage, Cohort Studies, Enterocolitis, Necrotizing, Female, Humans, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Inflammation, Male, Maternal Exposure, Pregnancy, Pregnancy Complications, Retinopathy of Prematurity, Risk Factors, Sepsis

OBJECTIVE: To evaluate the relationship between prenatal and postnatal inflammation-related risk factors and severe retinopathy of prematurity (ROP).

STUDY DESIGN: The study included infants born <30 weeks in California from 2007 to 2011. Multivariable log-binomial regression was used to assess the association between prenatal and postnatal inflammation-related exposures and severe ROP, defined as stage 3-5 or surgery for ROP.

RESULTS: Of 14,816 infants, 10.8% developed severe ROP. Though prenatal inflammation-related risk factors were initially associated with severe ROP, after accounting for the effect of these risk factors on gestational age at birth through mediation analysis, the association was non-significant (P = 0.6). Postnatal factors associated with severe ROP included prolonged oxygen exposure, sepsis, intraventricular hemorrhage, and necrotizing enterocolitis.

CONCLUSION: Postnatal inflammation-related factors were associated with severe ROP more strongly than prenatal factors. The association between prenatal inflammation-related factors and ROP was explained by earlier gestational age in infants exposed to prenatal inflammation.

Alternate JournalJ Perinatol
PubMed ID30932029
PubMed Central IDPMC6592770
Grant ListF32 HD091945 / HD / NICHD NIH HHS / United States