|Title||Prenatal and postnatal inflammation-related risk factors for retinopathy of prematurity.|
|Publication Type||Journal Article|
|Year of Publication||2019|
|Authors||Goldstein GP, Leonard SA, Kan P, Koo EB, Lee HC, Carmichael SL|
|Date Published||2019 07|
|Keywords||Bronchopulmonary Dysplasia, Cerebral Intraventricular Hemorrhage, Cohort Studies, Enterocolitis, Necrotizing, Female, Humans, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Inflammation, Male, Maternal Exposure, Pregnancy, Pregnancy Complications, Retinopathy of Prematurity, Risk Factors, Sepsis|
OBJECTIVE: To evaluate the relationship between prenatal and postnatal inflammation-related risk factors and severe retinopathy of prematurity (ROP).
STUDY DESIGN: The study included infants born <30 weeks in California from 2007 to 2011. Multivariable log-binomial regression was used to assess the association between prenatal and postnatal inflammation-related exposures and severe ROP, defined as stage 3-5 or surgery for ROP.
RESULTS: Of 14,816 infants, 10.8% developed severe ROP. Though prenatal inflammation-related risk factors were initially associated with severe ROP, after accounting for the effect of these risk factors on gestational age at birth through mediation analysis, the association was non-significant (P = 0.6). Postnatal factors associated with severe ROP included prolonged oxygen exposure, sepsis, intraventricular hemorrhage, and necrotizing enterocolitis.
CONCLUSION: Postnatal inflammation-related factors were associated with severe ROP more strongly than prenatal factors. The association between prenatal inflammation-related factors and ROP was explained by earlier gestational age in infants exposed to prenatal inflammation.
|Alternate Journal||J Perinatol|
|PubMed Central ID||PMC6592770|
|Grant List||F32 HD091945 / HD / NICHD NIH HHS / United States|