Title | Neuroimaging and Bayley-III correlates of early hand function in extremely preterm children. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Duncan AF, Bann CM, Dempsey AG, Adams-Chapman I, Heyne R, Hintz SR |
Corporate Authors | Eunice Kennedy Shriver National Institute of Child Health and Development Neonatal Research Network |
Journal | J Perinatol |
Volume | 39 |
Issue | 3 |
Pagination | 488-496 |
Date Published | 2019 03 |
ISSN | 1476-5543 |
Keywords | Brain, Cohort Studies, Developmental Disabilities, Echoencephalography, Female, Hand, Humans, Infant, Infant, Extremely Premature, Linear Models, Magnetic Resonance Imaging, Male, Neuropsychological Tests |
Abstract | OBJECTIVE(S): Investigate associations between 18 and 22-month corrected age hand function, adverse findings on serial cranial ultrasound (CUS) and near-term brain MRI (ntMRI), and Bayley-III scores in extremely preterm (EPT) toddlers. STUDY DESIGN: Cohort analysis of Neonatal Research Network SUPPORT NEURO data. Associations between brain abnormalities, hand function, and Bayley-III scores were examined using chi-square and generalized linear mixed effect model analyses. RESULTS: A total of 433 children were included. Sixteen percent had hand function deficits; these were associated with late CUS (p < 0.001) abnormalities, white matter abnormality (WMA) on ntMRI (p < 0.001), and Bayley-III scores. Six percent had CP. Fourteen percent of children without and 50% of those with CP had hand function abnormalities. CONCLUSIONS: Late CUS findings and severity of WMA were significantly associated with hand function deficits. Hand function deficits were nearly three times more common than CP and may be a useful marker of early brain insult and predictor of preterm birth effects on development. |
DOI | 10.1038/s41372-019-0314-0 |
Alternate Journal | J Perinatol |
PubMed ID | 30692613 |
PubMed Central ID | PMC7092795 |
Grant List | U10 HD021373 / HD / NICHD NIH HHS / United States UG1 HD087226 / HD / NICHD NIH HHS / United States |