| Title | 28 NICUs participating in a quality improvement collaborative targeting early-onset sepsis antibiotic use. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Payton KSE, Bennett MV, Schulman J, Benitz WE, Stellwagen L, Darmstadt GL, Quinn J, Kristensen-Cabrera AI, Breault CC, Bolaris M, Lefrak L, Merrill J, Sharek PJ |
| Journal | J Perinatol |
| Date Published | 2024 Feb 20 |
| ISSN | 1476-5543 |
| Abstract | OBJECTIVE: There is widespread overuse of antibiotics in neonatal intensive care units (NICUs). The objective of this study was to safely reduce antibiotic use in participating NICUs by targeting early-onset sepsis (EOS) management. STUDY DESIGN: Twenty-eight NICUs participated in this statewide multicenter antibiotic stewardship quality improvement collaborative. The primary aim was to reduce the total monthly mean antibiotic utilization rate (AUR) by 25% in participant NICUs. RESULT: Aggregate AUR was reduced by 15.3% (p < 0.001). There was a wide range in improvement among participant NICUs. There were no increases in EOS rates or nosocomial infection rates related to the intervention. CONCLUSION: Participation in this multicenter NICU antibiotic stewardship collaborative targeting EOS was associated with an aggregate reduction in antibiotic use. This study informs efforts aimed at sustaining improvements in NICU AURs. |
| URL | https://pubmed.ncbi.nlm.nih.gov/38378826/ |
| DOI | 10.1038/s41372-024-01885-8 |
| Alternate Journal | J Perinatol |
| PubMed ID | 38378826 |
| PubMed Central ID | 7848759 |
