|Title||Association between small-for-gestational age and neurocognitive impairment at two years of corrected age among infants born at preterm gestational ages: a cohort study.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Girsen AI, Do SC, El-Sayed YY, Hintz SR, Blumenfeld YJ|
|Date Published||2017 08|
|Keywords||Birth Weight, Child, Preschool, Cohort Studies, Female, Gestational Age, Humans, Infant, Newborn, Infant, Premature, Infant, Small for Gestational Age, Mental Status and Dementia Tests, Neurocognitive Disorders, Severity of Illness Index, Statistics as Topic, United States|
OBJECTIVE: To investigate the association between small-for-gestational age (SGA) and neurocognitive impairment at 2 years of corrected age among infants born at preterm gestational ages.
STUDY DESIGN: A secondary analysis of a prospectively conducted NICHD/Maternal-Fetal Medicine Units BEAM trial. Non-anomalous pregnancies delivered before 37 weeks of gestation were included in the analysis. Neurocognitive outcomes at 2 years of corrected age were compared between infants who were SGA (<10% for gestational age) and those appropriately grown (AGA). The primary outcome was a severe or moderate neurocognitive impairment at 2 years of corrected age among survivors, defined as either mental (MDI) or psychomotor (PDI) developmental index score <70 for severe and <85 for moderate impairment.
RESULTS: Of 2299 preterm neonates 67 (3%) were SGA. SGA infants were more often twin pregnancies (31% vs 17%, P=0.003) and delivered more often by cesarean section (63% vs 40%, P<0.001) at similar gestational ages (30.0±2.6 vs 29.5±2.8 weeks, P=0.11). At 2 years of corrected age, SGA and AGA survivors had similar rates of neurocognitive impairment (MDI <70: 18% vs 18%, P=1.0; MDI <85: 44% vs 46%, P=0.96; PDI <70: 20% vs 15%, P=0.51; PDI <85: 40% vs 34%, P=0.48).
CONCLUSION: In this cohort, SGA at preterm gestational ages was associated with similar rates of neurocognitive impairment at two years of corrected age among surviving infants.
|Alternate Journal||J Perinatol|
|PubMed Central ID||PMC5800317|
|Grant List||UG1 HD068268 / HD / NICHD NIH HHS / United States|