|Title||Childhood outcomes after hypothermia for neonatal encephalopathy.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Shankaran S, Pappas A, McDonald SA, Vohr BR, Hintz SR, Yolton K, Gustafson KE, Leach TM, Green C, Bara R, Huitema CMPetrie, Ehrenkranz RA, Tyson JE, Das A, Hammond J, Peralta-Carcelen M, Evans PW, Heyne RJ, Wilson-Costello DE, Vaucher YE, Bauer CR, Dusick AM, Adams-Chapman I, Goldstein RF, Guillet R, Papile L-A, Higgins RD|
|Corporate Authors||Eunice Kennedy Shriver NICHD Neonatal Research Network|
|Journal||N Engl J Med|
|Date Published||2012 May 31|
|Keywords||Asphyxia Neonatorum, Cerebral Palsy, Child, Preschool, Developmental Disabilities, Female, Humans, Hypothermia, Induced, Hypoxia-Ischemia, Brain, Infant, Newborn, Intellectual Disability, Intelligence, Intelligence Tests, Male|
BACKGROUND: We previously reported early results of a randomized trial of whole-body hypothermia for neonatal hypoxic-ischemic encephalopathy showing a significant reduction in the rate of death or moderate or severe disability at 18 to 22 months of age. Long-term outcomes are now available.
METHODS: In the original trial, we assigned infants with moderate or severe encephalopathy to usual care (the control group) or whole-body cooling to an esophageal temperature of 33.5°C for 72 hours, followed by slow rewarming (the hypothermia group). We evaluated cognitive, attention and executive, and visuospatial function; neurologic outcomes; and physical and psychosocial health among participants at 6 to 7 years of age. The primary outcome of the present analyses was death or an IQ score below 70.
RESULTS: Of the 208 trial participants, primary outcome data were available for 190. Of the 97 children in the hypothermia group and the 93 children in the control group, death or an IQ score below 70 occurred in 46 (47%) and 58 (62%), respectively (P=0.06); death occurred in 27 (28%) and 41 (44%) (P=0.04); and death or severe disability occurred in 38 (41%) and 53 (60%) (P=0.03). Other outcome data were available for the 122 surviving children, 70 in the hypothermia group and 52 in the control group. Moderate or severe disability occurred in 24 of 69 children (35%) and 19 of 50 children (38%), respectively (P=0.87). Attention-executive dysfunction occurred in 4% and 13%, respectively, of children receiving hypothermia and those receiving usual care (P=0.19), and visuospatial dysfunction occurred in 4% and 3% (P=0.80).
CONCLUSIONS: The rate of the combined end point of death or an IQ score of less than 70 at 6 to 7 years of age was lower among children undergoing whole-body hypothermia than among those undergoing usual care, but the differences were not significant. However, hypothermia resulted in lower death rates and did not increase rates of severe disability among survivors. (Funded by the National Institutes of Health and the Eunice Kennedy Shriver NICHD Neonatal Research Network; ClinicalTrials.gov number, NCT00005772.).
|Alternate Journal||N Engl J Med|
|PubMed Central ID||PMC3459579|
|Grant List||U10 HD027856 / HD / NICHD NIH HHS / United States |
U10 HD021373 / HD / NICHD NIH HHS / United States
U10 HD021385 / HD / NICHD NIH HHS / United States
U10 HD040461 / HD / NICHD NIH HHS / United States
KL2 RR024149 / RR / NCRR NIH HHS / United States
UL1 TR000454 / TR / NCATS NIH HHS / United States
UL1 RR024148 / RR / NCRR NIH HHS / United States
UL1 RR025008 / RR / NCRR NIH HHS / United States