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Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort.

CPQCC Publication
TitleExtreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort.
Publication TypeJournal Article
Year of Publication2018
AuthorsVohr BR, Heyne R, Bann CM, Das A, Higgins RD, Hintz SR
Corporate AuthorsEunice Kennedy Shriver National Institute of Child Health, and Development Neonatal Research Network
JournalJ Pediatr
Volume200
Pagination132-139.e3
Date Published2018 09
ISSN1097-6833
KeywordsBody Mass Index, Child, Female, Humans, Incidence, Infant, Low Birth Weight, Infant, Premature, Male, Neurodevelopmental Disorders, Neuroimaging, Obesity, Overweight, Prognosis, Risk Factors, Schools, United States
Abstract

OBJECTIVE: To identify rates of overweight (body mass index [BMI] ≥85th percentile) and obesity (BMI ≥95th percentile) at 6-7 years of age and associated risk factors among extremely preterm infants born at <28 weeks of gestation.

STUDY DESIGN: Anthropometrics, blood pressure, and active and sedentary activity levels were prospectively assessed. Three groups were compared, those with a BMI ≥85th percentile (overweight or obese for age, height, and sex) and ≥95th percentile (obese) vs <85th percentile. Multiple regression analyses estimated the relative risks of BMI ≥85th percentile and ≥95th percentile associated with perinatal and early childhood factors.

RESULTS: Of 388 children, 22% had a BMI of ≥85th percentile and 10% were obese. Children with obesity and overweight compared with normal weight children had higher body fat (subscapular skinfold and triceps skinfold >85th percentile), central fat (waist circumference >90th percentile), spent more time in sedentary activity (20.5 vs 18.2 vs 16.7 hours/week), and had either systolic and/or diastolic hypertension (24% vs 26% vs 14%), respectively. Postdischarge weight gain velocities from 36 weeks postmenstrual age to 18 months, and 18 months to 6-7 years were independently associated with a BMI of ≥85th percentile, whereas weight gain velocity from 18 months to 6-7 years was associated with obesity.

CONCLUSIONS: One in 5 former extremely preterm infants is overweight or obese and has central obesity at early school age. Postdischarge weight gain velocities were associated with overweight and obesity. These findings suggest the obesity epidemic is spreading to the most extremely preterm infants.

TRIAL REGISTRATION: ClinicalTrials.gov: NCT00063063 and NCT0000.

DOI10.1016/j.jpeds.2018.04.073
Alternate JournalJ Pediatr
PubMed ID29793869
PubMed Central IDPMC6109599
Grant ListU10 HD021385 / HD / NICHD NIH HHS / United States
U10 HD053119 / HD / NICHD NIH HHS / United States
U10 HD021364 / HD / NICHD NIH HHS / United States
UG1 HD053089 / HD / NICHD NIH HHS / United States
U10 HD040461 / HD / NICHD NIH HHS / United States
U10 HD027904 / HD / NICHD NIH HHS / United States
UG1 HD034216 / HD / NICHD NIH HHS / United States
UG1 HD027904 / HD / NICHD NIH HHS / United States
U10 HD027851 / HD / NICHD NIH HHS / United States
UG1 HD021364 / HD / NICHD NIH HHS / United States
UG1 HD027880 / HD / NICHD NIH HHS / United States
UG1 HD053109 / HD / NICHD NIH HHS / United States
UG1 HD027851 / HD / NICHD NIH HHS / United States
U10 HD053089 / HD / NICHD NIH HHS / United States
U10 HD027856 / HD / NICHD NIH HHS / United States
U10 HD021373 / HD / NICHD NIH HHS / United States
UG1 HD087226 / HD / NICHD NIH HHS / United States
U10 HD053124 / HD / NICHD NIH HHS / United States
U10 HD027880 / HD / NICHD NIH HHS / United States
UG1 HD027853 / HD / NICHD NIH HHS / United States
U10 HD053109 / HD / NICHD NIH HHS / United States
UG1 HD087229 / HD / NICHD NIH HHS / United States
UG1 HD040689 / HD / NICHD NIH HHS / United States
U10 HD040689 / HD / NICHD NIH HHS / United States
U10 HD040492 / HD / NICHD NIH HHS / United States
U10 HD034216 / HD / NICHD NIH HHS / United States
U10 HD036790 / HD / NICHD NIH HHS / United States
UG1 HD068278 / HD / NICHD NIH HHS / United States
U24 HD095254 / HD / NICHD NIH HHS / United States