Title | The Relationship of Nosocomial Infection Reduction to Changes in Neonatal Intensive Care Unit Rates of Bronchopulmonary Dysplasia. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Lapcharoensap W, Kan P, Powers RJ, Shaw GM, Stevenson DK, Gould JB, Wirtschafter DD, Lee HC |
Journal | J Pediatr |
Volume | 180 |
Pagination | 105-109.e1 |
Date Published | 2017 01 |
ISSN | 1097-6833 |
Keywords | Bronchopulmonary Dysplasia, Cohort Studies, Cross Infection, Female, Humans, Infant, Newborn, Intensive Care Units, Neonatal, Male, Retrospective Studies, Time Factors |
Abstract | OBJECTIVE: To examine whether recent reductions in rates of nosocomial infection have contributed to changes in rates of bronchopulmonary dysplasia (BPD) in a population-based cohort. STUDY DESIGN: This was a retrospective, population-based cohort study that used the California Perinatal Quality Care Collaborative database from 2006 to 2013. Eligible infants included those less than 30 weeks' gestational age and less than 1500 g who survived to 3 days of life. Primary variables of interest were rates of nosocomial infections and BPD. Adjusted rates of nosocomial infections and BPD from a baseline period (2006-2010) were compared with a later period (2011-2013). The correlation of changes in rates across periods for both variables was assessed by hospital of care. RESULTS: A total of 22 967 infants from 129 hospitals were included in the study. From the first to second time period, the incidence of nosocomial infections declined from 24.7% to 15% and BPD declined from 35% to 30%. Adjusted hospital rates of BPD and nosocomial infections were correlated positively with a calculated 8% reduction of BPD rates attributable to reductions in nosocomial infections. CONCLUSIONS: Successful interventions to reduce rates of nosocomial infections may have a positive impact on other comorbidities such as BPD. The prevention of nosocomial infections should be viewed as a significant component in avoiding long-term neonatal morbidities. |
DOI | 10.1016/j.jpeds.2016.09.030 |
Alternate Journal | J. Pediatr. |
PubMed ID | 27742123 |