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OASCN Resources | Early-Onset Sepsis (EOS) Impact of Prolonged Antibiotic Use

These resources were developed by the OASCN Collaborative between 2021-2022.

Relevant Didactics:

  • Duration of Empiric Antibiotic Therapy for Neonatal Sepsis: How much is Enough? (Ken Zangwill): Slides | Video

Relevant References: 

Ting JY et al. Duration of initial empirical antibiotic therapy and outcomes in very low birth weight infants. Pediatrics. 2019;143(3):e20182286. doi: 10.1542/peds.2018-2286.

Underwood MW et al. Neonatal intestinal dysbiosis. J Perinatol 2020; 40, pages1597–1608(2020)

Singer JR et al. Preventing dysbiosis of the neonatal mouse intestinal microbiome protects against late-onset sepsis. Nat Med 2019; 25: 1772.

Greenberg RC et al. Prolonged duration of early antibiotic therapy in extremely premature infants. Pediatr Res. 2019 Jun;85(7):994-1000.